To date, the business operates as a complex system tantamount to a living organism, in this regards, businesses affect variables in the environment that they operate in a dynamic, liquid and interdependent way. Ecosystemic and sustainable business approach drives us to know businesses as complex systems which have many predictable and unpredictable variables internally and externally within the company or organization, depending on their environments across space and time. A cause-effect linear approach might not be sufficient to foster innovation to develop a sustainable business that is able to survive in the era of  VUCA (volatility, uncertainty, complexity, and ambiguity). To enable business to be sustainable, they must become adaptive, innovative, self-determined, self-aware and resource-led. The challenge for future businesses face problems such as climate change, ecosystem degradation, digital innovative disruption, poverty, economic instability etc. In response, innovative understandings of business practices and sustainability are necessary to develop novel and complex models for businesses to respond to the contemporary and future challenges. This conference is expected to contribute to the literature on sustainable business strategy not only from theoretical point of view but also from practical point of view.